amino acids synthesis

By Targets:	Amino Acid Derivatives (7) Apoptosis (3) Autophagy (3) Bacterial (2) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (3) Isotope-Labeled Compounds (3) PEPCK (1) PROTAC Linkers (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (4)

Targets Recommended: Amino Acid Derivatives DNA/RNA Synthesis EAAT Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W041076

3,5-Difluoro-DL-phenylalanine

Amino Acid Derivatives Others

3,5-Difluoro-DL-phenylalanine is a phenylalanine derivative that can be used for amino acids synthesis .
HY-W048209

Fmoc-Lys(Palmitoyl)-OH

Amino Acid Derivatives Others

Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis .

3,5-Difluoro-DL-phenylalanine	Amino Acid Derivatives	Others
3,5-Difluoro-DL-phenylalanine is a phenylalanine derivative that can be used for amino acids synthesis .

Fmoc-Lys(Palmitoyl)-OH	Amino Acid Derivatives	Others
Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis .

HY-B0511

Biotin Maximum Cited Publications 8 Publications Verification Vitamin B7; Vitamin H; D-Biotin	Endogenous Metabolite	Metabolic Disease
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-79404A

Boc-beta-t-butyl-d-alanine

Boc-beta-t-butyl-d-alanine is an intermediate, can be used in the synthesis of peptides and other amino acids .
HY-W016330

H-His(1-Me)-OMe

Amino Acid Derivatives Others

H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis .

Boc-beta-t-butyl-d-alanine
Boc-beta-t-butyl-d-alanine is an intermediate, can be used in the synthesis of peptides and other amino acids .

H-His(1-Me)-OMe	Amino Acid Derivatives	Others
H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis .

HY-B0863

Glyphosate
Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

HY-B0511A

Biotin sodium Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium	Endogenous Metabolite	Metabolic Disease
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-23212A

2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride	Others	Cancer
2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride is a non-protein amino acid, sulfamic acid.2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride contains one amino group and two terminal carboxylic acids.2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride has a variety of physiological functions, including maintaining the stability of cell membranes, regulating cholesterol metabolism, supporting the normal function of the nervous system, participating in collagen synthesis, and anti-oxidation .

HY-77635

Z-D-Chg-OH

Amino Acid Derivatives Others

Z-D-Chg-OH is a glycine derivative that can be used for amino acid synthesis .

Z-D-Chg-OH	Amino Acid Derivatives	Others
Z-D-Chg-OH is a glycine derivative that can be used for amino acid synthesis .

HY-B0863S

Glyphosate-d2	Isotope-Labeled Compounds Apoptosis Autophagy
Glyphosate-d₂ is the deuterium labeled Glyphosate. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[1].

HY-B0863R

Glyphosate (Standard)	Apoptosis Autophagy	Cancer
Glyphosate (Standard) is the analytical standard of Glyphosate. This product is intended for research and analytical applications. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

HY-130695

N-(Amino-PEG5)-N-bis(PEG4-acid)	PROTAC Linkers	Cancer
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids .

HY-B0863S2

Glyphosate-d2-1	Apoptosis Autophagy	Cancer
Glyphosate-d₂-1 is the deuterium labeled Glyphosate[1]. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[2].

HY-133803

Z-Ala-Ala-OH

Amino Acid Derivatives Others

Z-Ala-Ala-OH is a non-polar amino acid that can be used in enzymatic peptide synthesis .

Z-Ala-Ala-OH	Amino Acid Derivatives	Others
Z-Ala-Ala-OH is a non-polar amino acid that can be used in enzymatic peptide synthesis .

HY-131514

L-Ornithine 2-oxoglutarate Ornithine α-ketoglutarate; OKG	Others	Inflammation/Immunology
L-Ornithine 2-oxoglutarate (Ornithine alpha-ketoglutarate) is a nutritional compound that is a salt of amino acids with antioxidant and anti-inflammatory effects. L-Ornithine 2-oxoglutarate stimulates the production of insulin and growth hormone, and promotes intracellular amino acid transport and protein synthesis .

HY-B0863S3

Glyphosate-13C2,15N	Isotope-Labeled Compounds	Cancer
Glyphosate- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labled Glyphosate (HY-B0863). Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

HY-I1124

L-Valine-d8 L-VALINE-2,3,4,4,4,5,5,5-d₈	Isotope-Labeled Compounds	Others
L-Valine-d₈ is a deuterated form of L-Valine. L-Valine-d₈ can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].

HY-W007390

Methyl 2-amino-5-bromobenzoate	Bacterial	Infection
Methyl 2-amino-5-bromobenzoate (compound 8/12) can be used for synthesis of 2-benzamidobenzoic acids, which are known FabH inhibitors. The derivates also inhibit PqsD, the pqs quorum sensing (QS) system of Pseudomonas aeruginosa, involving the production of a number of virulence factors and biofilm formation .

HY-141147

7-O-(Amino-PEG4)-paclitaxel	Drug-Linker Conjugates for ADC	Cancer
7-O-(Amino-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Amino-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) .

HY-W013097

Boc-Arg(di-Z)-OH	Amino Acid Derivatives	Others
Boc-Arg(di-Z)-OH can be used for the synthesis of amino acid. Boc-Arg(di-Z)-OH can be used for the research of inhibitors for processing proteinases. Boc-Arg(di-Z)-OH is coupled via the mixed anhydride (MA) with HGlu(OBzl)-Lys(Z)-Arg(Z,Z)-CH2Cl .

HY-W042005

H-D-Phe(3,4-DiCl)-OH	Amino Acid Derivatives	Others
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity .

HY-128923

SKF-34288 hydrochloride 1 Publications Verification 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride	PEPCK	Metabolic Disease
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (K_i: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides .

HY-W010382

Oxaloacetic acid 2-Oxosuccinic acid	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .

HY-W142092

N-Acetyl-DL-serine	Bacterial	Others
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .

HY-141148

7-O-(Cbz-N-amido-PEG4)-paclitaxel	Drug-Linker Conjugates for ADC	Cancer
7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Cbz-N-amido-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs) .

Cat. No.	Product Name

HY-L064

Glutamine Metabolism Compound Library	903 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 903 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Glutamine Metabolism Compound Library

903 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 903 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Target	Research Area

HY-W041076

3,5-Difluoro-DL-phenylalanine

Amino Acid Derivatives Others

3,5-Difluoro-DL-phenylalanine is a phenylalanine derivative that can be used for amino acids synthesis .
HY-W048209

Fmoc-Lys(Palmitoyl)-OH

Amino Acid Derivatives Others

Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis .
HY-77635

Z-D-Chg-OH

Amino Acid Derivatives Others

Z-D-Chg-OH is a glycine derivative that can be used for amino acid synthesis .
HY-W016330

H-His(1-Me)-OMe

Amino Acid Derivatives Others

H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis .

3,5-Difluoro-DL-phenylalanine	Amino Acid Derivatives	Others
3,5-Difluoro-DL-phenylalanine is a phenylalanine derivative that can be used for amino acids synthesis .

Fmoc-Lys(Palmitoyl)-OH	Amino Acid Derivatives	Others
Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis .

Z-D-Chg-OH	Amino Acid Derivatives	Others
Z-D-Chg-OH is a glycine derivative that can be used for amino acid synthesis .

H-His(1-Me)-OMe	Amino Acid Derivatives	Others
H-His(1-Me)-OMe is a histidine derivative that can be used for amino acid synthesis .

HY-P3596

GHRF, mouse Mouse growth hormone-releasing factor	Peptides	Endocrinology
GHRF, mouse, a mouse growth hormone-releasing factor, is a peptide containing 44 amino acids. GHRF, mouse stimulates the release and synthesis of growth hormone .

HY-W013097

Boc-Arg(di-Z)-OH	Amino Acid Derivatives	Others
Boc-Arg(di-Z)-OH can be used for the synthesis of amino acid. Boc-Arg(di-Z)-OH can be used for the research of inhibitors for processing proteinases. Boc-Arg(di-Z)-OH is coupled via the mixed anhydride (MA) with HGlu(OBzl)-Lys(Z)-Arg(Z,Z)-CH2Cl .

HY-W042005

H-D-Phe(3,4-DiCl)-OH	Amino Acid Derivatives	Others
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity .

HY-W142092

N-Acetyl-DL-serine	Bacterial	Others
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .

Cat. No.	Product Name

HY-K1046

L-Glutamine (100×), Sterile
L-glutamine is an important amino acid supplement commonly added to mammalian cell culture media. L-glutamine serves as an auxiliary energy source, especially when cells are rapidly dividing. L-glutamine is also important in the production of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate, other amino acids, and plays a role in protein synthesis and glucose production.

L-Glutamine (100×), Sterile

L-glutamine is an important amino acid supplement commonly added to mammalian cell culture media. L-glutamine serves as an auxiliary energy source, especially when cells are rapidly dividing. L-glutamine is also important in the production of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate, other amino acids, and plays a role in protein synthesis and glucose production.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0511

Biotin 5+ Cited Publications Vitamin B7; Vitamin H; D-Biotin	Structural Classification other families Microorganisms Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-W010382

Oxaloacetic acid 2-Oxosuccinic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other disease Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .

HY-B0511A

Biotin sodium Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-B0863R

Glyphosate (Standard)	Microorganisms Source classification	Apoptosis Autophagy
Glyphosate (Standard) is the analytical standard of Glyphosate. This product is intended for research and analytical applications. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

Cat. No.	Product Name	Chemical Structure

HY-B0863S

Glyphosate-d2
Glyphosate-d₂ is the deuterium labeled Glyphosate. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[1].

HY-B0863S3

Glyphosate-13C2,15N
Glyphosate- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labled Glyphosate (HY-B0863). Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants .

HY-I1124

L-Valine-d8
L-Valine-d₈ is a deuterated form of L-Valine. L-Valine-d₈ can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].

HY-B0863S2

Glyphosate-d2-1
Glyphosate-d₂-1 is the deuterium labeled Glyphosate[1]. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[2].

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